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Adipotide

FTPP (Fat-Targeted Pro-apoptotic Peptide), CKGGRAKDC-GG-D(KLAKLAK)2

Research useEducational entry
Mechanism

A synthetic chimeric peptidomimetic combining a homing motif (CKGGRAKDC, which binds prohibitin on white-adipose-tissue endothelium) with a pro-apoptotic domain, D(KLAKLAK)2. In animal models it is studied for inducing apoptosis of the blood vessels that supply white fat, causing the fat tissue to regress.

Evidence

Preclinical only — rodent and non-human primate (obese rhesus monkey) data. No completed human clinical trials. Reversible kidney (renal) toxicity was observed in primates. Not an approved drug.

Applications
  • Studied in rodents for adipose-tissue reduction
  • Non-human primate obesity models
  • Research into vasculature-targeted (anti-angiogenic) approaches to fat
Protocol

Educational overview only — no dosing instructions in the public hub.

Risks

Documented reversible renal toxicity in primate studies; no human safety data; not intended for human use. Sourcing/purity is an additional practical risk.

Quality

Third-party CoA (purity + quantification + MS) is the minimum verification.

Legal status

Research-use-only in most jurisdictions; not approved for human use anywhere. Never advanced past preclinical development.

Studies
Kolonin et al., Reversal of obesity by targeted ablation of adipose tissue, Nat Med 2004 ↗Barnhart et al., A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys, Sci Transl Med 2011 ↗
✓ Last reviewed · 2026-07-21

Frequently asked questions

What is Adipotide used for?
Studied in rodents for adipose-tissue reduction. Non-human primate obesity models. Research into vasculature-targeted (anti-angiogenic) approaches to fat. Preclinical only — rodent and non-human primate (obese rhesus monkey) data. No completed human clinical trials. Reversible kidney (renal) toxicity was observed in primates. Not an approved drug.
Is Adipotide legal in Europe?
Research-use-only in most jurisdictions; not approved for human use anywhere. Never advanced past preclinical development.
What are the risks and side effects of Adipotide?
Documented reversible renal toxicity in primate studies; no human safety data; not intended for human use. Sourcing/purity is an additional practical risk.
How is the quality of Adipotide assessed?
Third-party CoA (purity + quantification + MS) is the minimum verification.