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Hexarelin

Examorelin, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2

Research useEducational entry
Mechanism

A synthetic hexapeptide growth hormone secretagogue that binds the ghrelin/GHS receptor (GHS-R1a) to stimulate pulsatile GH release; a potent secretagogue whose GH response can attenuate with repeated dosing (partial, reversible desensitisation).

Evidence

Human and animal pharmacology studies describe strong GH release and receptor desensitisation; no approved therapeutic indication. Not an approved drug.

Applications
  • Studied as a GH-secretagogue research probe
  • Investigated for cardiovascular signalling in preclinical models
  • Used to probe GHS-receptor pharmacology
Protocol

Educational overview only — no dosing instructions in the public hub.

Risks

Receptor desensitisation reduces response over time; can raise cortisol and prolactin; long-term human safety unknown; sourcing/purity is a major practical risk.

Quality

Third-party CoA (purity + quantification + MS) is the minimum verification.

Legal status

Research-use-only; not approved for human use in the EU, UK or US.

✓ Last reviewed · 2026-07-21

Frequently asked questions

What is Hexarelin used for?
Studied as a GH-secretagogue research probe. Investigated for cardiovascular signalling in preclinical models. Used to probe GHS-receptor pharmacology. Human and animal pharmacology studies describe strong GH release and receptor desensitisation; no approved therapeutic indication. Not an approved drug.
Is Hexarelin legal in Europe?
Research-use-only; not approved for human use in the EU, UK or US.
What are the risks and side effects of Hexarelin?
Receptor desensitisation reduces response over time; can raise cortisol and prolactin; long-term human safety unknown; sourcing/purity is a major practical risk.
How is the quality of Hexarelin assessed?
Third-party CoA (purity + quantification + MS) is the minimum verification.