Family · metabolic
Mazdutide
IBI362, LY3305677
An oxyntomodulin-based dual glucagon (GCG) and GLP-1 receptor agonist; GLP-1 activity supports insulin secretion and satiety while glucagon activity may raise energy expenditure and act on hepatic fat metabolism.
Supported by phase 3 trials (DREAMS, GLORY) mainly in Chinese adults; approved in China but still investigational elsewhere, with no FDA or EMA authorisation.
- Studied for chronic weight management in overweight/obesity
- Studied for glycaemic control in type 2 diabetes
- Investigated for hepatic fat/metabolic endpoints
Educational overview only — no dosing instructions in the public hub. Where authorised it is a prescription medicine used under medical supervision.
Most reported effects are gastrointestinal (nausea, diarrhoea, vomiting) typical of incretin drugs; long-term safety outside trial and Chinese-approval settings is not established.
Approved supply exists only in China via licensed channels; any 'research' vials sold elsewhere are unapproved and carry purity, dosing and safety risk.
Approved by China's NMPA (weight management and type 2 diabetes, 2025); investigational and not approved by the FDA or EMA.
Frequently asked questions
- What is Mazdutide used for?
- Studied for chronic weight management in overweight/obesity. Studied for glycaemic control in type 2 diabetes. Investigated for hepatic fat/metabolic endpoints. Supported by phase 3 trials (DREAMS, GLORY) mainly in Chinese adults; approved in China but still investigational elsewhere, with no FDA or EMA authorisation.
- Is Mazdutide legal in Europe?
- Approved by China's NMPA (weight management and type 2 diabetes, 2025); investigational and not approved by the FDA or EMA.
- What are the risks and side effects of Mazdutide?
- Most reported effects are gastrointestinal (nausea, diarrhoea, vomiting) typical of incretin drugs; long-term safety outside trial and Chinese-approval settings is not established.
- How is the quality of Mazdutide assessed?
- Approved supply exists only in China via licensed channels; any 'research' vials sold elsewhere are unapproved and carry purity, dosing and safety risk.