Family · sexual
Gonadorelin
GnRH, LHRH, Gonadorelin acetate/hydrochloride (Factrel, Lutrepulse)
Synthetic decapeptide identical to native gonadotropin-releasing hormone (GnRH); acts on pituitary GnRH receptors to stimulate LH and FSH release. Pulsatile delivery mimics physiology; continuous exposure downregulates the axis.
A well-characterised medicine with human clinical use, unlike research-only peptides. Historically used as a GnRH stimulation test and, via pump, for pulsatile therapy in hypothalamic amenorrhea. Half-life is very short (minutes).
- Diagnostic GnRH stimulation test of pituitary function
- Pulsatile therapy for congenital / hypothalamic hypogonadotropic conditions
- Fertility / ovulation-induction research
Educational overview only — no dosing instructions in the public hub.
A prescription medicine when used clinically; risks depend on setting (e.g. injection reactions, over/under-stimulation). Non-prescription sourcing raises purity and safety concerns.
Third-party CoA (purity + quantification + MS) is the minimum verification.
A prescription medicine (GnRH), not a research-only compound. Available in several EU/UK jurisdictions for diagnostic/fertility use; branded US products (Factrel, Lutrepulse) were commercially withdrawn, leaving access via compounding.
Frequently asked questions
- What is Gonadorelin used for?
- Diagnostic GnRH stimulation test of pituitary function. Pulsatile therapy for congenital / hypothalamic hypogonadotropic conditions. Fertility / ovulation-induction research. A well-characterised medicine with human clinical use, unlike research-only peptides. Historically used as a GnRH stimulation test and, via pump, for pulsatile therapy in hypothalamic amenorrhea. Half-life is very short (minutes).
- Is Gonadorelin legal in Europe?
- A prescription medicine (GnRH), not a research-only compound. Available in several EU/UK jurisdictions for diagnostic/fertility use; branded US products (Factrel, Lutrepulse) were commercially withdrawn, leaving access via compounding.
- What are the risks and side effects of Gonadorelin?
- A prescription medicine when used clinically; risks depend on setting (e.g. injection reactions, over/under-stimulation). Non-prescription sourcing raises purity and safety concerns.
- How is the quality of Gonadorelin assessed?
- Third-party CoA (purity + quantification + MS) is the minimum verification.