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Triptorelin

Triptorelin, Decapeptyl, Trelstar, Diphereline, Triptodur

Research useEducational entry
Mechanism

A synthetic decapeptide GnRH (gonadotropin-releasing hormone) agonist. Initial dosing paradoxically stimulates LH/FSH release (the 'flare' effect) with a short-lived rise in sex hormones; continuous or depot exposure then down-regulates pituitary GnRH receptors, causing profound and sustained suppression of testosterone/estrogen (reversible medical castration).

Evidence

Well-established prescription drug. FDA-approved (Trelstar) for advanced prostate cancer in 2000; used internationally (Decapeptyl, Diphereline) across several hormone-dependent conditions.

Applications
  • Advanced prostate cancer (androgen deprivation)
  • Endometriosis and uterine fibroids
  • Central precocious puberty
  • Adjunct in assisted-reproduction protocols
Protocol

Educational overview only — no dosing instructions in the public hub. Prescription depot drug administered under specialist supervision.

Risks

Initial 'flare' can transiently worsen prostate-cancer symptoms (bone pain, urinary obstruction); hypogonadism effects — hot flushes, reduced bone density, sexual dysfunction, mood changes, metabolic and cardiovascular considerations. Prescription-only; use requires medical oversight.

Quality

A regulated pharmaceutical product should be obtained only through licensed pharmacies with a valid prescription; batch/label integrity and cold-chain matter.

Legal status

Approved prescription medicine (Rx) in the US, EU and most jurisdictions; not a research-use-only compound and not available over the counter.

✓ Last reviewed · 2026-07-21

Frequently asked questions

What is Triptorelin used for?
Advanced prostate cancer (androgen deprivation). Endometriosis and uterine fibroids. Central precocious puberty. Adjunct in assisted-reproduction protocols. Well-established prescription drug. FDA-approved (Trelstar) for advanced prostate cancer in 2000; used internationally (Decapeptyl, Diphereline) across several hormone-dependent conditions.
Is Triptorelin legal in Europe?
Approved prescription medicine (Rx) in the US, EU and most jurisdictions; not a research-use-only compound and not available over the counter.
What are the risks and side effects of Triptorelin?
Initial 'flare' can transiently worsen prostate-cancer symptoms (bone pain, urinary obstruction); hypogonadism effects — hot flushes, reduced bone density, sexual dysfunction, mood changes, metabolic and cardiovascular considerations. Prescription-only; use requires medical oversight.
How is the quality of Triptorelin assessed?
A regulated pharmaceutical product should be obtained only through licensed pharmacies with a valid prescription; batch/label integrity and cold-chain matter.